Vicenin -2

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Vicenin 2 是一种血管紧张素转换酶 (ACE) 抑制剂 (IC50=43.83 μM)，来自 Desmodium styracifolium 的地上部分。 Vicenin 2 是 α-葡萄糖苷酶、PTP1B 和 RLAR 的抑制剂。

Vicenin 2 is an angiotensin-converting enzyme (ACE) inhibitor (IC50=43.83 μM) from the aerial parts of Desmodium styracifolium. Vicenin 2 is an inhibitor of α-glucosidase, PTP1B, and RLAR. Vicenin -2 has hepatoprotective, anti-cancer, antioxidant and anti-inflammatory activities, and DTL co-administration is more effective than either of the single agents in androgen-independent prostate cancer.?Vicenin -2 might be a useful lead for the development of multiple target-oriented therapeutic modalities for the treatment of diabetes and diabetes-associated complications.?Vicenin -2 could act as a UV light barrier to protect the plants.

Cell Viability Assay Cell Line:NCI-H23 cells Concentration:10 μM, 20 μM, 30 μM, 40 μM, 50 μM, 60 μM, 70 μM, 80 μM, 90 μM, 100 μM Incubation Time:24 hours Result:Showed cytotoxic effect on NCI?H23 cells.

Animal Model:Male C57BL/6J mice (25 g) treated with Dextran sulfate sodium (DSS)Dosage:50 mg/kg Administration:Orally administration; for 7 days Result:Effectively suppressed DSS-induced colitis by attenuating expressions of key inflammatory mediators.

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Endocrinology/Hormones

RAAS

ACE

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23666-13-9

594.5

C27H30O15

>98% (HPLC)

DMSO:10 mM

C1=CC(=CC=C1C2=CC(=O)C3=C(C(=C(C(=C3O2)[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)O)O

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(-20℃)

With Ice Pack

≥ 2 years